Semaglutide, Tirzepatide and other GLP/GIP Medications for Weight Loss

What are they?

Semaglutide and Tirzepatide resemble peptides your body makes all by itself. In higher doses, they help your body produce more insulin when your blood sugar levels are too high. It also works in the GI tract by slowing gastric motility and keeping food in your stomach longer to prolong the feeling of fullness. For that reason, it can be a great weight loss aid. Tirzepatide is like semaglutide but also has a second way to help control appetite and increase weight loss. Brand names for these generics are:

Tirzepatide (sample brand names: Zepbound, Mounjaro)
Semaglutide (sample brand names: Wegovy, Ozempic)
Liraglutide (sample brand name: Saxenda)
Retatrutide (new)

Can I take them if I am not Diabetic?

Sold under the brand names such as Ozempic®, Wegovy® and Rybelsus®, Semaglutide is a prescription medication for type 2 diabetes and long-term weight management. Semaglutide was researched and approved by the FDA as an antidiabetic medication and weight-loss medication, but you don’t need to have type 2 diabetes to experience the benefits. A randomized controlled trial from 2021 found Semaglutide was an effective weight loss drug for overweight and obese non-diabetic adults. It may also lower your risk of obesity-related conditions such as heart attack and stroke.

Unfortunately, these brand name versions are very expensive and only covered by insurance if you have type 2 diabetes. They are available thru FDA approved compounding pharmacies at a much lower price.

What are the side effects?

While considered safe and effective medication for many people struggling with weight loss or type 2 diabetes management, they may have potential side effects including nausea, vomiting, diarrhea, abdominal pain, heartburn, constipation, or burping. In rare cases, they can cause serious side effects, some of which may require medical attention. That said, adverse reactions are usually limited to mild gastrointestinal upset.